ABSTRACT
This study evaluated the ability of ions from a non-alcoholic calcium hydroxide-propolis paste to diffuse through dentinal tubules. Thirty-six single-rooted bovine teeth were used. The tooth crowns were removed, and the root canals were instrumented and divided into 3 groups: Group 1 - calcium hydroxide-propylene glycol paste; Group 2 - calcium hydroxide-saline solution paste; Group 3 - calcium hydroxide-propolis paste. After the root canal dressings were applied, the teeth were sealed and placed in containers with deionized water. The pH of the water was measured after 3, 24, 72 and 168 hours to determine the diffusion of calcium hydroxide ions through the dentinal tubules. All of the pastes studied promoted the diffusion of calcium hydroxide ions through the dentinal tubules. Associating propolis to calcium hydroxide resulted in a pH increase, which occurred with greater intensity after 72 hours. The calcium hydroxide-propolis paste was able to diffuse in dentin.
Subject(s)
Animals , Cattle , Anti-Infective Agents/pharmacokinetics , Calcium Hydroxide/pharmacokinetics , Dentin/chemistry , Propolis/pharmacokinetics , Anti-Infective Agents/chemistry , Calcium Hydroxide/chemistry , Diffusion , Dental Pulp Cavity/chemistry , Dental Pulp Cavity/drug effects , Dentin/drug effects , Hydrogen-Ion Concentration , Ions/pharmacokinetics , Materials Testing , Propolis/chemistry , Root Canal Preparation , Time FactorsABSTRACT
OBJECTIVE: Removable partial dentures (RPD) require different hygiene care, and association of brushing and chemical cleansing is the most recommended to control biofilm formation. However, the effect of cleansers has not been evaluated in RPD metallic components. The aim of this study was to evaluate in vitro the effect of different denture cleansers on the weight and ion release of RPD. MATERIAL AND METHODS: Five specimens (12x3 mm metallic disc positioned in a 38x18x4 mm mould filled with resin), 7 cleanser agents [Periogard (PE), Cepacol (CE), Corega Tabs (CT), Medical Interporous (MI), Polident (PO), 0.05 percent sodium hypochlorite (NaOCl), and distilled water (DW) (control)] and 2 cobalt-chromium alloys [DeguDent (DD), and VeraPDI (VPDI)] were used for each experimental situation. One hundred and eighty immersions were performed and the weight was analyzed with a high precision analytic balance. Data were recorded before and after the immersions. The ion release was analyzed using mass spectrometry with inductively coupled plasma. Data were analyzed by two-way ANOVA and Tukey HSD post hoc test at 5 percent significance level. RESULTS: Statistical analysis showed that CT and MI had higher values of weight loss with higher change in VPDI alloy compared to DD. The solutions that caused more ion release were NaOCl and MI. CONCLUSIONS: It may be concluded that 0.05 percent NaOCl and Medical Interporous tablets are not suitable as auxiliary chemical solutions for RPD care.
Subject(s)
Chromium Alloys/pharmacokinetics , Denture, Partial, Removable , Denture Cleansers/pharmacology , Analysis of Variance , Biofilms/drug effects , Immersion , Ions/pharmacokinetics , Mass Spectrometry , Materials Testing , Surface Properties , Time FactorsABSTRACT
Cobalt [II], copper [II], nickel [II] and zinc [II] complexes of cephalosporin class of antibiotics - ceporex and velosef have been synthesised and characterized. The pharmacological assay of the metal-antibiotic complexes have shown to be more antibacterial than the simple antibiotics against bacteria such as streptococcus pyogenes, salmonella arizona, staphylococcus aureus and klebsiella pneumoniae